Astrocytes, traditionally non-immune cells within the central nervous system, possess the ability to develop an immune memory, responding more vigorously to subsequent immune challenges. This groundbreaking study reveals that through an epigenetic mechanism involving the enzymes p300 and ATP-citrate lyase (ACLY), astrocytes enhance their pro-inflammatory responses, a trait similar to the immune memory seen in adaptive immunity.
Astrocytes, traditionally non-immune cells within the central nervous system, possess the ability to develop an immune memory, responding more vigorously to subsequent immune challenges. This groundbreaking study reveals that through an epigenetic mechanism involving the enzymes p300 and ATP-citrate lyase (ACLY), astrocytes enhance their pro-inflammatory responses, a trait similar to the immune memory seen in adaptive immunity.
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